In this talk, we will discuss the creation of the Palliative Ham Reduction and Resiliency Clinic at The Ohio State Wexner Medical Center. This is a Palliative Medicine clinic with additional resources and support for patients with concurrent SUDs—including additional psycho-social support, substance use evaluation and management, and coordination of care. We provide care for patients with active cancer and concurrent substance misuse. We will discuss implementing a culture of (1) patient-centeredness, (2) safety, (3) collaboration, and (4) addiction support into our clinic model. We will also discuss our philosophy on safer opioid prescribing and harm reduction.